Professor Leonid P. TITOV

 

 

 

Professor Leonid. P. TITOV, Doctor of Medical Sciences, Immunologist

 

 

 PERSONAL HISTORY

 

Family name: TITOV
First name: Leonid
Patronymic: Petrovich
Date of birth: October 3, 1946
Nationality: Belarus
Family status: Married, two sons
Languages: English – reading, speaking. (except mother tongue)

 

Office Address:
Republican Research & Practical Center for Epidemiology & Microbiology (RRPCEM)
23 Filimonova Str., 220114, Minsk, Republic of Belarus
Telephone: +375-172 37 69 98
Fax: +375-172 67 30 93
E-mail: leonidtitov@tut.by

 

 

1969-1975 -- State Medical Institute in Minsk, Faculty of Sanitation and Hygiene (Honours Diploma of Medical Doctor).

 

SPECIALTY BOARD CERTIFICATION

 

1975-1978 -- Postgraduate course at the department of Microbiology, State Medical Institute, thesis under the title "Studies on factors of of nonspecific immunity in patients with chronic infectious diseases of the upper respiratory tract". Degree of Candidate of Medical Sci. (Microbiology), awarded at the State Medical Institute in Minsk.

 

1991 -- Degree of Doctor of Medical Sci. (in clinical immunology and allergology) awarded at Medical Institute (Kiev, Ukraine). Thesis under the title "Physiological and pathophysiological aspects of complement system functions".

 

1992 -- The position of a Professor was confirmed.

 

 

1983 -- A 3-month training course in the field of microbiology at the Department of Microbiology, Immunology, Virology of the Institute for Sanitary and Hygiene (St.-Petersburgh, Russia)

 

1989 -- A 1-month training course in modern problems of microbiology, immunology, virology at the Ist Medical Institute (Moscow).

 

1994 -- Upgrading stage (training course) within the Microbiology Exchange Programme on Anaerobic Bacteriology at the Department of Microbiology of the Medical School at the Udine University, Italy.

 

1995 -- Training course in immunology at the Pediatrics Department of the Amien University (France).

 

1996 -- Short training course in allergology and immunology within the Programme of the American College of Allergy, Asthma & Immunology (Boston, USA).

 

1997 -- Short training international course in immuno-rheumatology (Cuenca, Equador).

 

2002 -- Short training course in allergology and immunology within the American College of Allergy, Asthma & Immunology Scientific Conference (Boston, USA).

 

 

09.2009-up till now  -- Head of the Laboratory of Microbiology & Immunology at the Republican Research & Practical Center for Epidemiology and Microbiology (RRPCEM) of the Ministry of Health, Republic of Belarus

 

03.1995-09.2009 -- Director of the Research Institute for Epidemiology and Microbiology (RIEM) of the Ministry of Health, Republic of Belarus.

 

1999-2006 -- Head of the Division of Microbiology & Immunology at the Research Institute for Epidemiology and Microbiology (RIEM) of the Ministry of Health, Republic of Belarus.

 

1988-2006 --  Head of the Department of Microbiology, Immunology, Virology at Belarusian State Medical University  in Minsk.

 

1987-1988 -- Head of the Laboratory of Children Immunology at State Medical Institute in Minsk.

 

1986-1987 -- Docent of the Department of Microbiology, Immunology, Virology at State Medical Institute in Minsk.

 

1979-1986 -- Assistant of the Department of Microbiology, Immunology and Virology at State Medical Institute in Minsk.

 

 

1986 -- Head of the Programme of the investigations of radiation effects on children"s immune system and immunological monitoring of children, residing on radionuclide-contaminated territories.
1990-1992 -- National Immunization Programme and Programme of Immunologic Services Development were designed.

 

1994 -- International Medical Commission in the city of Bhopal (India) to evaluate effects  of a gas  disaster (1984) on the health of victims (immunoecological part of the project - tuberculosis and immune system function).

 

1996-2000 -- Head of the State Scientific-Technical Programme "Infectious Diseases".

 

1998-2000 -- Co-partner from Belarus side in the EC international project ”Optimization of prevention and surveillance of poliomyelitis and other enteroviruse infections” (IC15-CT96-0912).

 

1999-2001 -- Co-partner from Belarus side in the EC international project ”Microbiological surveillance of diphtheria in the Eastern Europe” (IC15-CT98-0302).

 

2000-2003 -- Co-partner from Belarus side in the EC international project ENVRAD “Long-term effects of DNA damage in persons exposed to radioactively contaminated environment” (ICA2-CT-2000-10047)

 

2001-2010 -- Head of the State Scientific-Technical Programme “Infectious Diseases and Medical Biotechnology”

 

2001-2004 -- Co-partner from Belarus side in the Swiss National Science Foundation international project (SCOPES 2001-2004) “Autoantibodies, a link between chronic infectious and autoimmune diseases. AntiC1q autoantibodies: friend or foe?” (7BYPJ065654.1)

 

2002-2004 -- Co-partner from Belarus side in the EC international project “Study of the role of non-toxigenic Corynebacterium diphtheriae in the epidemiology of diphtheria” (INTAS-2001-2289)

 

2006-2009 -- Co-partner from Belarus side in the EC international project “The role of human genetic factors in the immune control of HIV-1: analysis of unique cohort of a single-source HIV-1 outbreak eliminates confounding effects of virus genetic diversity” (INTAS Ref. Nr 05-1000004-7749).

 

 

I. Basic Immunology. Natural Immunity. Mechanisms of natural resistance and antigen non-specific immunoreactivity, as the most essential and unique form of organism protection. The regularities of complement system functioning, the role of its components in numerous infections, allergic and autoimmune diseases, functional and biochemical methods of complement system studies. Autoantibodies, natural antibodies, Th1/Th2 regulation.

 

II. Ecologic Immunology. Influence of ecologic factors of biologic, physical and chemical nature on human immune system. Damages in the immune system of healthy individuals as a decisive point to form immunodependent pathology. Effects of small radiation doses on immune status in early and late post-Chernobyl accident periods. Immune system functions in children, residing on radionuclide-contaminated territories, methods of immunocorrection.

 

III. Clinical and Experimental Immunology. Functions of T-system immunity, immunoregulation; mechanisms of hypersensitivity (delayed type) formation as an effector link in the cellular immunity. Individual immunoreactivity (antigen specific response/non-responsiveness) of the organism to bacterial antigens and mitogens, which allow to increase diagnosis efficacy in infectious diseases (AIDS, hepatitis B & C, tuberculosis, klebsielosis, chlamydiosis, trichinellosis etc.); methods of immune reactivity estimation and new approaches to immunocorrection, tumor immunology - immunology of lung cancer.

 

IV. Bacteriology. Clinical bacteriology (anaerobic bacteria – Clostridium difficile, bacteroides, gram-negative bacteria – family of Enterobacteriacceae) and Corynebacterium diphtheriae. Hospital infections monitoring of the resistance bacteria to antibiotics). Molecular-genetic investigation of the Mycobacteria tuberculosis infection.

 

V. Virology. Viral hepatitis B and C, rabies, HIV, measles, human enteroviruses, polioviruses, arboviruses (West Nile virus).

 

 

Scientific Fellow of the American College of Allergy, Asthma & Immunology (2003).

 

The National State Premium for the cycle of works in the field of “New Technologies of Prophylactic and Ecologic Medicine” (2003).

 

 

Member of the Russian Medical & Technical Academy of Sciences (1998).
Associate Member of the National Academy of Sciences of Belarus (2000).
Member of the American College of Allergy, Asthma & Immunology (2003).
Member of the European Academy of Allergy, Asthma and Clinical Immunology (2003).
Foreign Member of the Russian Academy of Medical Sciences (2004).
Member of the Federation of the European Microbiological Societies (FEMS representative in Belarus)
Member of the European Scientific Society of Clinical Children Immunology and Allergology as well as of the International Immunocompromised Host Society
Member of the International Union of Immunologic Societies
Chairman of the Belarusian Scientific Society of Epidemiologists, Microbiologists and Parasitologists
Vice-Chairman of the Belarusian Scientific Society of Immunologists and Allergologists
Member of the European Working Group on Diphtheria

 

 

Central-European Journal of Immunolgy (Poland)
Zh. of Microbiology, Epidemiology and Immunology (Russia)
Voprosy Virusologii (Russia)
Zdravookhranenie (Belarus)
Medicine (Belarus)
Proceedings of the National Academy of Sciences of Belarus, Series of Medical Sciences (Belarus)
News of Biomedical Sciences (Belarus)

 

Participant of more than 50 international conferences and meetings. More then 20 of the immunologic and microbiologic conferences were organized under my leadership in Belarus in 1982-2009, invited speaker to several scientific conferences.

 

List of International Conferences which were organized under my leadership in Belarus:
1. Immunostatus and Radiation. Gomel, 1991.
2. Chenobyl Disaster Post-Effects: Now and Tomorrow. Gomel, 1994.
3. Global Control of Viral Hepatitis. Minsk, 1997.
4. Problems of Bacteriology & Immunology. Minsk, 1999.
5. Infection and Immunity. Minsk, 1999.
6. Global Control of Viral Hepatitis and AIDS. Minsk, 1999.
7. 5th International Forum on Global Vaccinology “Vaccines and Immunization”, Minsk, 2001.
8. Role of Antropogenic and Natural Pathogens in Infectious and Non-infectious Human Diseases. Medical and Ecological Aspects, Minsk, 2002.
9. Resistance of Microorganisms to Antimicrobial Preparations, Minsk, 2003.
10. 6th International Forum on Global Vaccinology “Vaccines and Immunization”, Minsk, 2003.
11. Problems of Infectious Pathology of the 21 Century, Minsk, 2004.
12. Day of Immunology, Minsk, 2005.
13. International GA2LEN Symposium on Allergology in Belarus, Minsk, 2005.
14. Problems of Bacteriology and Immunology, Minsk, 2005.
15. International Scientific and Practical Conference “Molecular Diagnosis of Infectious Diseases”, Minsk, 2007.
16. International Scientific and Practical Conference “Current Problems of Human Infectious Pathology”, Minsk, 2008.
17. International Scientific and Practical Conference “Current Problems of Human Infectious Pathology”, Minsk, 2009

 

 

The author and co-author of more than 800 scientific publications, 50% from them are papers (mostly in Russian).
The author of 19 inventions and patents.
Books & monographs:
1) Krasilnikov A.P., Kazak N.F., Titov L.P. Vocabulary on General and Medical Virology. Minsk: Vysheyshaya Shkola. 1995. 63 p. (In Belarusian);
2) Mishaeva N.P., Votiakov V.I., Titov L.P. Rabies and another Lyssaviral Infections of Human. Minsk: Khata, 2002. 283 p. (In Russian);
3)  Immunology: Terminological Dictionary. Minsk: Belarusian State Medical University. 2004. 351 p. (In Russian)

 

 

Under my scientific direction 9 doctoral and 32 candidate theses had been carried out.